Across
- 1. Ligand released by osteoblasts which bind to osteoclast precursor cells and stimulate osteoclast maturation
- 6. Hormone released by the thyroid gland to inhibit osteoclast activity
- 8. Type of bone that has a honeycomb-like appearance and is a high target area for bone remodelling
- 9. Hormone that under physiological conditions, increases osteoclast activity but when given in low doses therapeutically can increase bone mass
- 10. A complex skeletal disease characterised by low bone density and micro-architectural defects in bone tissue, resulting in increased bone fragility and susceptibility to fracture
- 11. Bone resorption plays a critical role in the homeostasis of this physiologically important ion
- 12. A side effect of bisphosphonates, typically occurring in the jaw
- 14. Fully differentiated mesenchymal stem cells that synthesis bone
Down
- 1. A selective oestrogen receptor modulator that has a similar effect on bone as human oestrogen
- 2. A commonly used nitrogen-containing bisphoshponate
- 3. Class of drugs that mimics the structure of pyrophosphate which decrease osteoclast activity
- 4. Cells that were previously osteoblasts which have now buried themselves within bone matrix and have large processes extending outwards
- 5. A type of anti-inflammatory medicine used to treat a range of conditions but increases the risk of developing osteoporosis
- 7. Multinucleated cells that absorb bone tissue during bone remodelling, formed by the fusion of many monocytes
- 13. Class of drugs that have a similar structure to oestrogen and exert a similar role but are slightly more selective than oestrogen itself
- 14. Produced by osteoblasts and bind to RANKL to block its activity on osteoclasts