PAH Disease State

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Across
  1. 4. Decreased ejection fraction of the RV is reflective of an __________ afterload
  2. 7. PVR is a measure of RV _________________
  3. 11. mPAP correlates _______ with PAH symptoms
  4. 13. It is important to maintain RV _________ in the treatment of RV failure
  5. 16. Decreases in the area of the distal PA’s results in an elevated ______________ ______________ __________________
  6. 21. The RV can _______ with an acute increase in PVR
  7. 22. Myocardial _______________ may be a contributor to decreased ventricular compliance in RV failure
  8. 23. Myocardial metabolism switches from fatty acid oxidation to _______________
  9. 28. Programmed cell death is called _________________
  10. 30. Pulmonary venous hypertension has a PAWP that is _______________ than 15
  11. 32. In the pulmonary circulation, resistance and compliance are ________________ related to each other
  12. 33. The RV and LV do not move as a unit and have __________________
  13. 35. Doppler echo evaluates the ________________ PAP
  14. 36. This test can be used to evaluate RV systolic performance
  15. 37. An increase in mPAP that is due to increased downstream pressure is ________________ PH
Down
  1. 1. In maladaptive remodeling BNP will be ____________________
  2. 2. This happens to the 6MWD with increasing RV dilitation. ____________
  3. 3. Acidosis causes __________________ of the pulmonary vasculature
  4. 5. An external stimulus that may contribute to the development of PH is ____________ ____________
  5. 6. The main cause of death in IPAH patients is _____ _______________
  6. 8. The vena cava should ____________ with inspiration in healthy subjects
  7. 9. Exercise _____________ is a strong predictor of survival in PAH
  8. 10. When we talk about the interaction between contractility and afterload we are referring to ventriculoarterial __________________
  9. 12. Pressure drop across the pulmonary circulation is called ______________ _______________
  10. 14. PVR reflects the functional status of the pulmonary vascular ___________________
  11. 15. The RV is _________________ shaped
  12. 17. RV contraction is ______________________ and not circumferential like the LV
  13. 18. One of the contributors to PH is pulmonary vascular wall ________________
  14. 19. PAH survival is closely related to RV ________________
  15. 20. A decrease in _____________ _________________ causes a similar change in 6MWD
  16. 24. Volume ______________ in PAH can worsen RF function
  17. 25. The normal pulmonary vascular has ______________ resting vascular tone
  18. 26. ________________ indicates a significant loss of cardiac reserve
  19. 27. The mean interval from onset of symptoms to diagnosis is ______ years
  20. 29. RV _____________ is a compensatory mechanism that occurs due to increased afterload
  21. 31. The performance of the RV is ______-load dependent
  22. 34. Patients with severe PAH have _____________ levels of uric acid