PAH Disease State

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Across
  1. 4. PAH survival is closely related to RV ________________
  2. 5. An increase in mPAP that is due to increased downstream pressure is ________________ PH
  3. 6. Decreased ejection fraction of the RV is reflective of an __________ afterload
  4. 7. The RV and LV do not move as a unit and have __________________
  5. 9. RV contraction is ______________________ and not circumferential like the LV
  6. 11. In the pulmonary circulation, resistance and compliance are ________________ related to each other
  7. 13. One of the contributors to PH is pulmonary vascular wall ________________
  8. 15. The performance of the RV is ______-load dependent
  9. 16. Doppler echo evaluates the ________________ PAP
  10. 17. A decrease in _____________ _________________ causes a similar change in 6MWD
  11. 19. The vena cava should ____________ with inspiration in healthy subjects
  12. 21. The mean interval from onset of symptoms to diagnosis is ______ years
  13. 22. Programmed cell death is called _________________
  14. 23. An external stimulus that may contribute to the development of PH is ____________ ____________
  15. 28. This happens to the 6MWD with increasing RV dilitation. ____________
  16. 31. Pressure drop across the pulmonary circulation is called ______________ _______________
  17. 34. The RV is _________________ shaped
  18. 35. The RV can _______ with an acute increase in PVR
  19. 36. Myocardial _______________ may be a contributor to decreased ventricular compliance in RV failure
Down
  1. 1. PVR reflects the functional status of the pulmonary vascular ___________________
  2. 2. The main cause of death in IPAH patients is _____ _______________
  3. 3. Patients with severe PAH have _____________ levels of uric acid
  4. 8. Decreases in the area of the distal PA’s results in an elevated ______________ ______________ __________________
  5. 10. The normal pulmonary vascular has ______________ resting vascular tone
  6. 12. When we talk about the interaction between contractility and afterload we are referring to ventriculoarterial __________________
  7. 14. Acidosis causes __________________ of the pulmonary vasculature
  8. 18. Volume ______________ in PAH can worsen RF function
  9. 20. mPAP correlates _______ with PAH symptoms
  10. 22. PVR is a measure of RV _________________
  11. 24. RV _____________ is a compensatory mechanism that occurs due to increased afterload
  12. 25. ________________ indicates a significant loss of cardiac reserve
  13. 26. In maladaptive remodeling BNP will be ____________________
  14. 27. Exercise _____________ is a strong predictor of survival in PAH
  15. 29. Myocardial metabolism switches from fatty acid oxidation to _______________
  16. 30. It is important to maintain RV _________ in the treatment of RV failure
  17. 32. This test can be used to evaluate RV systolic performance
  18. 33. Pulmonary venous hypertension has a PAWP that is _______________ than 15