Pain (Part 1): OCAT practice #3

3. Ionotropic glutamate receptor recruited during synaptic potentiation.
6. Theory proposing pain is recognized based on pattern of stimulation.
7. Unique property of NMDA receptors requiring multiple simultaneous signals.
8. Coincidence detecting glutamate receptor requiring depolarization and glycine.
10. Pain is this processed phenomenon, not just a stimulus.
12. Increased perception of an already painful stimulus.
13. Ascending tract carrying pain signals to the thalamus.
17. Prominent neuropeptide released in pain signalling.
18. Membrane shift required to relieve magnesium block of NMDA receptors.
21. Theory proposing spinal modulation of pain before reaching the brain.
22. Molecule in hot peppers that activates TRPV receptors.
24. Neurotransmitter that can reduce CGRP promoter activity.
27. Peripheral sensors that transduce noxious stimuli into neural signals.
28. Main inhibitory neurotransmitter that counteracts excitation in pain circuits.
29. Long term changes in synaptic strength underlying learning and memory.
30. Ion channel receptor that increases chloride flux to reduce action potentials.

1. Modern model integrating biological psychological and social influences on pain.
2. Early theory proposing pain occurs when stimulus intensity exceeds threshold.
4. Fibres carrying signals toward the central processing structures.
5. Pain perception from a normally nonpainful stimulus.
9. Reduced receptor responsiveness after prolonged stimulation.
11. Brain relay station for ascending nociceptive signals.
14. Capsaicin sensitive ion channel critical for sensing heat.
15. Region of the spinal cord where primary afferents synapse.
16. Main excitatory neurotransmitter in the CNS heavily involved in pain transmission.
19. Theory proposing separate pathways for different sensory modalities.
20. Peptide released from nociceptors and regulated partly by iNOS.
23. Descartes theory that pain is transmitted along nerve fibres to the brain.
25. Enzyme partly regulating CGRP synthesis in inflammatory signalling.
26. Metabotropic receptor that decreases cAMP and increases potassium conductance.
31. Organization responsible for publishing the most cited modern definition of pain.