Across
- 4. This is a statistical process which allows for the equalization of unknown bias between two groups
- 7. This antibiotic is highly implicated in the development of DILI
- 8. This type of analysis only includes participants who strictly adhere to the treatment they were originally assigned to
- 13. This is a form of analysis which breaks down study participants into groups based on shared characteristics to examine how an intervention affects different groups of people
- 14. This medication is the mainstay treatment for acetaminophen toxicity
- 15. The probability that the observed result happened by chance
- 16. An error in which the null hypothesis is rejected, when, in fact, it is true
- 18. This type of analysis includes all participants based on the group they were assigned to, regardless of whether they fully adhered to the treatment or dropped out of the study, preserving randomization
- 20. One of four most common etiologies which can cause AST and ALT > 1000
- 22. What type of liver injury is associated with R= 2-5
- 23. ratio This is a statistical measurement that compares the rate of a specific event occurring in one group over time to another group
- 25. This is a type of clinical study which compares a new treatment to an existing treatment to determine if the new treatment is not worse than the existing one
- 28. This bile acid sequestrant aids in treatment of pruritis in patients with cholestatic liver disease
- 29. Synthetic marker of liver function
Down
- 1. This mechanism of toxicity is related to damage to the mitochondria leading to issues with oxidative phosphorylation and apoptosis in patients with DILI
- 2. This is the claim that the effect being studied does not exist
- 3. One of four most common etiologies which can cause AST and ALT > 1000
- 5. This is a graph shows the probability of survival over time
- 6. What type of liver injury is associated with R >5
- 9. What type of liver injury is associated with R <2
- 10. This mechanism of toxicity is related to the involvement of the immune system in displaying DAMPs, and thereby liver injury, in patients with DILI
- 11. One of four most common etiologies which can cause AST and ALT > 1000
- 12. Corrective factor for p value/number of subgroups to reduce the risk of finding a significant finding by chance alone
- 17. Calculation used to determine location of injury based on ALT and Alk phos compared to their upper limits of normal
- 19. A type of clinical trial in which neither the researchers or the patients know which treatment the patients are receiving until the trial is over
- 20. The outcome to which the study is powered for
- 21. One of four most common etiologies which can cause AST and ALT > 1000
- 24. This pathognomic finding is seen on pathology for patients with primary sclerosing cholangitis
- 26. Name of the trial studied in this week's journal club
- 27. bias This form of bias impacts the external validity of a study because of unequal likelihoods of selection of all individuals within a population