Pharm Week 7 - Sedation/Hypnotics

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Across
  1. 6. Barbiturate drug with highest CNS effect; anesthesia
  2. 8. Benzodiazepine-like drug; GABA receptor action, maintains sleep
  3. 9. Barbiturate drug with low-medium CNS effect; sleep sustenance
  4. 11. Low dose will cause ____
  5. 15. Adverse effects of Zolpidem include drowsiness and ___ related behaviors
  6. 16. Adverse effects of Benzodiazepines include mild increase CO, increased BP with increased dose, drowsiness, amnesia, _____ reactions (old/young)
  7. 17. Sedative-Hypnotic drugs are dose ____
  8. 19. MOA: Orexin Antagonist; All of the sleep purposes; No adverse effects
  9. 20. This class of drug includes Lorazepam, Diazepam, and Alprazolam; Safer with fewer effects than barbituartes; little respiratory effects expect IV midazolam
  10. 21. Low-Medium dose will cause _____; no loss of consciousness
  11. 22. Adverse effects of Zaleplon include drowsiness, _____ and sleep related behaviors
  12. 23. MOA: 5HT receptor; Use: Anxiolytic (short term; Adverse effects include Dizziness and nausea
  13. 25. Barbiturate drug with medium-high CNS effect; insomnia
  14. 26. Benzodiazepine-like drug; potentiates GABA, rapid, used for insomnia, sleep onset, and sleep maintenance
  15. 27. Barbiturates are fairly ______ (suicide risk, respiratory depression, abuse)
Down
  1. 1. Medium-High dose will cause _____; sleep-like effect
  2. 2. Benzodiazepine-like drug; potentiates GABA, short term sleep onset
  3. 3. Drug that reverses sedative effects of benzos; undo with "flu"; can cause rebound seizures, doesn't undo respiratory depression
  4. 4. High dose will cause ______, unconscious effect
  5. 5. _____ potential with tolerance of Benzodiazepines
  6. 7. Barbiturate drug with lowest CNS effect; anti-seizure
  7. 10. Adverse effects of Barbiturates include respiratory depression, cough, sneeze, ______, and increasing BP
  8. 12. MOA: MT1 agonist; Use: sleep onset; No adverse effects
  9. 13. _____ does not equal pharmacological effects; accumulate with repeated dosing
  10. 14. Benzodiazepine drug that is good for elderly, immediate half life, no active metabolites, and metabolism is not slowed by age
  11. 18. Barbiturate drug with medium CNS effect; insomnia
  12. 20. Adverse effects of Eszo-Piclone include _____ taste and dry mouth
  13. 23. Increase hepatic drug metabolism (even of self) which leads to tolerance
  14. 24. Benzodiazepines are ____ pregnancy safe but are lipid soluble