Pharmacodynamics

1. When the relationship between receptor occupancy and response in linear, Kd ____ EC50
4. molecule is used to prevent signal transduction
6. IC50 is always ______ than Ki
7. effective concentration to reach 50% maximal response
9. The antagonist concentration at which half of the agonist effect is inhibited
12. quantity of drug delivered/administered
13. amount of drug in a given compartment
14. the concentration/dose required to produce an effect of a given intensity
15. the lower the Kd, the higher the:
17. resulting changes in function
19. type of ligand that activates downstream signaling without selective activation of a single pathway

2. a drug-receptor interaction is based on random coupling of ligand-receptor
3. When 50% receptor occupancy occurs at higher concentration than half-maximal response, ______ are present
5. the maximal effect produced by a drug
8. chemical bonds between drug and receptor
10. This type of agonist can competitively inhibit the response of a full agonist
11. full occupancy of receptors by bound ligand
16. concentration at which 50% bound, 50% unbound
18. effective maximal concentration