Across
- 3. HIV drug for which all patients undergo a genetic test prior to administration
- 6. A single nucleotide locus with two or more naturally occurring alleles defined by a single base pair substitution
- 7. When two different alleles are present on the chromosome pair
- 10. An individual’s collection of genes
- 13. Two non-functional alleles and therefore have little to no enzyme activity
- 14. The basic physical unit of inheritance
- 16. The absorption, distribution, metabolism, and excretion (ADME) of bioactive drugs following their administration
- 17. A variant that has two or more alleles and is present at a frequency of at least 1% of the population
- 18. Variants in this gene can cause severe reactions in response to carbamazepine and abcavir
- 19. A precursor (forerunner) of a drug needs to undergo chemical conversion by metabolic processes before becoming an active pharmacological agent
- 20. A study to assess common genetic variations across the entire genome of a large population of individuals in order to study whether any of the investigated variations is associated with a phenotype of interest
Down
- 1. A collection of genetic variants, such as SNPs, that always travel together (are inherited together) on the same individual allele
- 2. Well know anticoagulant that causes severe side affects in certain individuals
- 4. A gene predicted to be associated with a particular trait e.g disease, adverse reaction to a drug
- 5. Can cause respiratory depression in some babies
- 8. Two normally functioning alleles and therefore have normal enzyme activity
- 9. Part of the genome formed by DNA sequences that encode genes
- 11. Maximum beneficial or therapeutic response that a drug can produce
- 12. A group of enzymes involved in drug metabolism and found in high levels in the liver
- 13. The biochemical and physiological effects of drugs, particularly those that define the drugs mechanism of action on the body
- 15. An unintended, harmful reaction to medicines