Pharmacokinetics

4. Percentage of drug that reaches systemic circulation after administration
9. Drug administration via the gastrointestinal tract
10. Movement of a drug across a membrane without energy use or transport protein
15. Theoretical amount describing drug dispersion in the body
16. Substance that increases the rate of drug metabolism
19. Substance that decreases the rate of drug metabolism
20. Active product of drug metabolism
22. Movement of a drug from the site of administration to the bloodstream
24. Route for which there is 100% bioavailability
25. Removal of drug from the body

1. The point where the drug concentration remains stable with repeated doses
2. Dose to continue therapeutic levels after steady state is reached
3. Actions of the drug on the body
5. Most prevalent protein in plasma and the most important of proteins to which drugs bind
6. Ionization state increasing a drug’s ability to cross membranes
7. Large initial dose to reach therapeutic levels more quickly
8. Most important organ for drug excretion
11. character allowing easier membrane crossing
12. Breakdown of drugs
13. Time it takes for the drug concentration to decrease by 50%
14. Movement of a drug from the bloodstream to various body tissues
17. Actions of the body on the drug
18. Organ responsible for first pass metabolism
21. Drug administration under the tongue for rapid absorption
23. Decreased response to a drug requiring higher doses over time