Pharmacokinetics II

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Across
  1. 6. Distribution of lipophilic drugs mainly depends on the ________ of the tissues
  2. 7. Highly _______ drugs can permeate the blood-brain barrier
  3. 8. Capillaries in the brain have a continuous lining of cells, separated by ______ junctions
  4. 9. A highly lipophilic drug (shows redistribution)
  5. 12. The principal biological compartments are divided by cell membranes &/ ________ walls
  6. 16. ________the size of the organ, higher the concentration gradient between blood and the organ
  7. 17. Bound drugs are pharmacologically _________
  8. 19. Only the ______ form of the drug can diffuse out of the vascular compartment
  9. 21. An intravenously administered drug which cannot cross the cell membrane will be retained in this compartment
  10. 22. The reversible movement of a drug to and from the blood and various tissues of the body
  11. 23. Competition between drugs for the same binding site may ___ be clinically significant
  12. 24. Drug binding to plasma proteins is reversible, saturable and _______
  13. 25. The protein-bound form of a drug helps _______ the duration of action
Down
  1. 1. A main drug binding protein
  2. 2. Plasma protein binding reduces the free drug concentration gradient and _______ across the capillary endothelial membrane
  3. 3. Mode of drug movement from the CSF to the brain tissues
  4. 4. This anticoagulant is confined to the intravascular compartment
  5. 5. This pharmacokinetic process is considered a mechanism of elimination
  6. 10. Free and bound fractions of the drug are in ________ with one another
  7. 11. Sinusoids and fenestrations allow the _______ of substances to the interstitial space
  8. 13. Drug distribution may be permeability-limited or affected by the _________ rate
  9. 14. Skeletal muscle can take up _______ amounts of a drug because of its large mass
  10. 15. This regulates drug entry into the CSF from the blood
  11. 18. Poorly perfused organs may not receive an adequate drug concentration if this pharmacokinetic process occurs rapidly
  12. 20. A bound drug can be displaced by another drug which shows _______ affinity to the same binding sites on the plasma proteins