Pharmacokinetics III

3. The glomerular filtration barrier restricts the passage of plasma macromolecules based on their size, shape and _______
7. Approximately,________ percent of the plasma entering the glomerulus is filtered
10. These transporters may operate by facilitated diffusion
14. A process of elimination
15. Diuresis ________ drug retention in the body
16. Organic Cation Transporters (OCTs)are _______ and do not need energy
17. _______ associated Resistance Proteins are considered the most important drug transporters
19. These proteins are especially important in the development of drug resistance
20. Excretion mainly occurs via _______

1. The mechanism involved in the termination of action of propofol and thiopental
2. Organic Anion Transporters (OATs) are _______
4. Membrane transporters may lead to drug resistance in anticonvulsant or _________ drug therapy
5. Administering methotrexate and NSAIDs together may give rise to ________
6. Probenecid _________ the duration of penicillin's therapeutic action
8. Transporters are proteins located on barrier _______ cell membranes throughout the body
9. The urine is _______ to manage aspirin overdose
11. Urine pH and urine ________ influence drug reabsorption
12. Drug transporters can either be influx or _____ transporters
13. Biliary excretion involves _____ transporters
18. Bile Salt Export Pump proteins are expressed in the _______