Across
- 1. — Class III antiarrhythmic that mainly blocks potassium channels, prolonging repolarization and refractory period. (Across)
- 4. — Synthetic T4 that is converted to T3 and binds thyroid-hormone receptors to regulate metabolic rate. (Down)
- 5. — Proton-pump inhibitor that irreversibly blocks the gastric parietal-cell H+/K+-ATPase. (Across)
- 7. — Inhibits fungal CYP450-dependent lanosterol 14-alpha-demethylase, reducing ergosterol synthesis. (Across)
- 9. — Angiotensin II receptor blocker that prevents angiotensin II from binding AT1 receptors. (Down)
- 15. — Vasopressin analogue acting at V2 receptors to increase renal water reabsorption. (Down)
- 16. — Dihydropyridine calcium-channel blocker that reduces calcium entry into vascular smooth muscle, causing vasodilation. (Across)
- 18. — Mu-opioid receptor agonist in the gut that decreases peristalsis and intestinal secretion. (Down)
- 19. — Activates insulin receptors, promoting cellular glucose uptake, glycogen synthesis, and lipogenesis. (Down)
- 20. — Selective beta1-adrenergic blocker that decreases heart rate, contractility, and renin release. (Across)
- 22. — Guanosine analogue phosphorylated by viral thymidine kinase; inhibits viral DNA polymerase. (Down)
- 24. — Recombinant erythropoietin that stimulates erythroid progenitor proliferation and red-blood-cell production. (Across)
- 29. — Aldosterone-receptor antagonist in the distal nephron, promoting sodium/water loss while sparing potassium. (Down)
- 32. — H2-receptor antagonist that reduces histamine-stimulated gastric acid secretion. (Down)
- 33. — Beta-lactam that inhibits bacterial cell-wall synthesis by binding penicillin-binding proteins. (Across)
- 34. — Nitrate that releases nitric oxide, increasing cGMP and dilating veins and coronary arteries. (Down)
- 35. clues
- 36. — Irreversibly inhibits cyclooxygenase-1, reducing thromboxane A2-mediated platelet aggregation. (Down)
- 37. — Bisphosphonate that inhibits osteoclast-mediated bone resorption. (Across)
Down
- 2. clues
- 3. — Selective beta2-adrenergic agonist that increases cAMP and relaxes bronchial smooth muscle. (Down)
- 6. — Dopamine D2-receptor antagonist and 5-HT4 agonist that enhances upper GI motility and has antiemetic effects. (Across)
- 8. — Loop diuretic that inhibits the Na+/K+/2Cl- cotransporter in the thick ascending limb of Henle. (Down)
- 10. — HMG-CoA reductase inhibitor that reduces hepatic cholesterol synthesis. (Down)
- 11. — Directly relaxes arteriolar smooth muscle, lowering peripheral vascular resistance and blood pressure. (Across)
- 12. — Glucocorticoid that suppresses inflammatory and immune gene transcription through intracellular glucocorticoid receptors. (Across)
- 13. — ACE inhibitor that prevents conversion of angiotensin I to angiotensin II, lowering aldosterone and blood pressure. (Across)
- 14. — Antimuscarinic that blocks muscarinic receptors in airway smooth muscle, causing bronchodilation. (Across)
- 17. — Inhibits mycolic-acid synthesis in the mycobacterial cell wall. (Down)
- 21. — Converts plasminogen to plasmin, promoting fibrin-clot breakdown. (Down)
- 23. — Irreversibly blocks the platelet P2Y12 ADP receptor, reducing platelet aggregation. (Across)
- 25. — Inhibits myocardial Na+/K+-ATPase, increasing intracellular calcium and strengthening cardiac contractility. (Down)
- 26. — Fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. (Down)
- 27. — Inhibits vitamin K epoxide reductase, reducing synthesis of vitamin K-dependent clotting factors II, VII, IX, and X. (Down)
- 28. — Decreases hepatic glucose production, increases insulin sensitivity, and activates AMPK. (Down)
- 30. — Binds glutamate-gated chloride channels in parasites, causing paralysis and death of the organism. (Across)
- 31. — Estrogen-receptor antagonist in the hypothalamus that increases GnRH, FSH, and LH secretion. (Across)