Pharmacology (General and Local Anesthetics)

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Across
  1. 1. The primary mechanism of local anesthetics is blockade of voltage-gated _______ channel
  2. 2. The anesthetic state is achieved when the partial pressure of the anesthetic in the brain reaches a threshold concentration determine by its
  3. 6. The Stage I in Guedel's signs
  4. 11. Are unique among the group of intravenous anesthetics in that their action can readily be terminated by administration of their selective antagonist, flumazenil
  5. 12. The easiest anesthetic end point to measure
  6. 13. Brand name of ketamine
  7. 15. Applied to mixtures in which the combination of elements has lower meting temp. than its component elements
  8. 16. Has limited application due to its poor block characteristics
  9. 19. Increase heart rate because they cause less depression of baroreceptor reflex
  10. 21. Brand name of levobupivacaine
  11. 22. Is a biologic toxins that bind to receptors within the channel and prevent inactivation
  12. 24. A partially water soluble and ligth lipid soluble phencyclidine derivative
  13. 27. It's pronounced lipophilicity has relegated its application to topical anethesia
  14. 28. Brand name of lidocaine
  15. 29. Had an excellent record as an intermediate duration anesthetic
  16. 30. Brand name of procaine
Down
  1. 1. Brand name of desflurane
  2. 3. Is largely restricted to topical anesthesia for ear,nose and throat procedures, where its intense vasoconstriction can serve to reduce bleeding
  3. 4. Use as an epidural agent in obstetrical anesthesia where its rapid hydrolysis served to minimize risk of systemic toxicity or fetal exposure
  4. 5. Brand name of articaine
  5. 7. Is likely to be associated with a decrease in cerebral blood flow without significant changes in ICP and CMRO2
  6. 8. Has the highest clearance of amino-amide anesthetic s
  7. 9. Circulating anesthetic also demonstrate _____________ effects having an impact on coagulation platelet aggregation and microcirculation
  8. 10. Is an S(-) enantiomer in a homologous series that includes bupivacaine and mepivacaine
  9. 14. Brand name of fospropofol
  10. 17. An increase in cardiac output and pulmonary blood flow will ________ uptake of anesthetic into the blood
  11. 18. Causes adrenocortical suppression by producing a dose dependent inhibition of 11 beta-hydroxylase
  12. 20. Used primarily for spinal anesthesia
  13. 23. Brand name of prilocaine
  14. 25. Is an alkyl phenol with hypnotic properties that is chemically distinct from other groups of intravenous anesthetics
  15. 26. Brand name of tetracaine