Across
- 1. The ratio between the toxic and therapeutic concentrations of a drug.
- 4. The development of congenital anomalies or defects in the developing fetus caused by the toxic effects of drugs.
- 6. An abnormal and unexpected response to a medication, other than an allergic reaction, that is peculiar to an individual patient.
- 9. A drug that binds to and inhibits the activity of one or more receptors in the body. Antagonists are also called inhibitors.
- 12. The initial metabolism in the liver of a drug is absorbed from the gastrointestinal tract before the drug reaches systemic circulation through the bloodstream.
- 14. The physiologic state in which the amount of drug removed via elimination is equal to the amount of drug absorbed with each dose. Substrates Substances (e.g., drugs or natural biochemicals in the body) on which an enzyme acts.
- 17. The desired or intended effect of a particular medication.
- 19. Within an artery (e.g., intraarterial injection).
- 20. The quality of being poisonous (i.e., injurious to health or dangerous to life).
- 21. The name given to a drug by the United States Adopted Names Council. Also called the nonproprietary name. The generic name is much shorter and simpler than the chemical name and is not protected by trademark.
- 23. An inactive drug dosage form that is converted to an active metabolite by various biochemical reactions once it is inside the body.
- 24. The processes involved in the interaction between a drug and body cells (e.g., the action of a drug on a receptor protein); also called mechanism of action.
- 25. A measure of the extent of drug absorption for a given drug and route (from 0% to 100%).
- 28. The process by which solid forms of drugs disintegrate in the gastrointestinal tract and become soluble before being absorbed into the circulation.
- 32. The chemical form of a drug that is administered before it is metabolized by the body into its active or inactive metabolites. prodrug is then metabolized to pharmacologically active metabolites.
- 33. Any chemical that affects the physiologic processes of a living organism.
- 35. A state in which there is a compulsive or chronic need, as for a drug.
- 38. Drug interactions in which the effect of a combination of two or more drugs with similar actions is equivalent to the sum of the individual effects of the same drugs given alone. For example, 1 + 1 = 2 (compare with synergistic effects).
- 39. Any unexpected, unintended, undesired, or excessive response to a medication given at therapeutic dosages (as opposed to overdose).
- 41. The time required for a drug to elicit a therapeutic response after dosing.
- 43. The general name for a large class of enzymes that plays a significant role in drug metabolism and drug interactions.
- 44. The treatment of pathologic conditions through the use of drugs.
- 47. The physiologic reactions of the body to a drug. They can be therapeutic or toxic and describe how the body is affected as a whole by the drug.
- 48. The broadest term for the study or science of drugs.
- 50. Within a joint (e.g., intraarticular injection).
- 53. Drug interactions in which the effect of a combination of two or more drugs is less than the sum of the individual effects of the same drugs given alone (1 + 1 equals less than 2); it is usually caused by an antagonizing (blocking or reducing) effect of one drug on another.
- 54. The characteristic that causes two parenteral drugs or solutions to undergo a reaction when mixed or given together that results in the chemical deterioration of at least one of the drugs.
- 55. The science of preparing and dispensing drugs, including dosage form design.
- 56. The study of the biochemical and physiologic interactions of drugs at their sites of activity. It examines the effect of the drug on the body.
- 57. deficiency A hereditary condition in which red blood cells break down when the body is exposed to certain drugs.
- 58. One or more biochemical reactions involving a parent drug; occur mainly in the liver and produce a metabolite that is either inactive or active. Also known as metabolism.
- 59. Any undesirable occurrence related to administering or failing to administer a prescribed medication.
Down
- 2. A drug that binds to and stimulates the activity of one or more receptors in the body.
- 3. Any preventable adverse drug event involving inappropriate medication use by a patient or health care professional; it may or may not cause patient harm. Medication use process The prescribing, dispensing, and administering of medications, and the monitoring of their effects.
- 5. The process of measuring drug levels to identify a patient’s drug exposure and to allow adjustment of dosages with the goals of maximizing therapeutic effects and minimizing toxicity.
- 7. Protein molecules that catalyze one or more of a variety of biochemical reactions, including those related to the body’s physiologic processes, as well as those related to drug metabolism.
- 8. A method of grouping drugs; may be based on structure or therapeutic use.
- 10. The time required for a drug to reach its maximum therapeutic response in the body.
- 11. Alteration in the pharmacologic or pharmacokinetic activity of a given drug caused by the presence of one or more additional drugs; it is usually related to effects on the enzymes required for metabolism of the involved drugs. Duration of action The length of time the concentration of a drug in the blood or tissues is sufficient to elicit a response.
- 13. The first form of a drug, or first in a class of drugs. Throughout this book, prototypical drugs will be denoted as “key drug.”
- 15. The study of the influence of genetic factors on drug response that result in the absence, overabundance, or insufficiency of drug-metabolizing enzymes.
- 16. Any condition, especially one related to a disease state or patient characteristic, including current or recent drug therapy, which renders a particular form of treatment improper or undesirable.
- 18. Drug interactions in which the effect of a combination of two or more drugs with similar actions is greater than the sum of the individual effects of the same drugs given alone. For example, 1 + 1 is greater than 2(compare with additive effects).
- 22. The study of poisons, including toxic drug effects, and applicable treatments.
- 25. The barrier system that restricts the passage of various chemicals and microscopic entities (e.g., bacteria, viruses) between the bloodstream and the central nervous system. It still allows for the passage of essential substances such as oxygen.
- 26. The lowest concentration of drug reached in the body after it falls from its peak level, usually measured in a blood sample for therapeutic drug monitoring.
- 27. A general term for any undesirable effects that are a direct response to one or more drugs.
- 29. The commercial name given to a drug product by its manufacturer; also called the proprietary name.
- 30. A chemical form of a drug that is the product of one or more biochemical (metabolic) reactions involving the parent drug (see later). Active metabolites are those that have pharmacologic activity of their own, even if the parent drug is inactive. Inactive metabolites lack pharmacologic activity and are simply drug waste products awaiting excretion from the body (e.g., via the urinary, gastrointestinal,or respiratory tract).
- 31. An immunologic hypersensitivity reaction resulting from the unusual sensitivity of a patient to a particular medication; a type of adverse drug event.
- 32. The maximum concentration of a drug in the body after administration, usually measured in a blood sample for therapeutic drug monitoring.
- 34. A transporter protein that moves drugs out of cells and into the gut, urine, or bile.
- 36. Reduced response to a drug after prolonged use.
- 37. In pharmacokinetics, the time required for half of an administered dose of drug to be eliminated by the body, or the time it takes for the blood level of a drug to be reduced by 50% (also called elimination half-life).
- 40. A molecular structure within or on the outer surface of a cell. Receptors bind specific substances (e.g., drug molecules), and one or more corresponding cellular effects drug actions) occur as a result of this drug-receptor interaction.
- 42. The study of what happens to a drug from the time it is put into the body until the parent drug and all metabolites have left the body. it represents the drug absorption into, distribution, and metabolism within, and excretion from the body.
- 45. The study of economic factors affecting the cost of drug therapy.
- 46. The condition of producing adverse bodily effects because of poisonous qualities.
- 49. The study of drugs that are obtained from natural plant and animal sources.
- 51. The name that describes the chemical composition and molecular structure of a drug.
- 52. Within a sheath (e.g., the theca of the spinal cord, as in an intrathecal injection into the subarachnoid space).