Pharmacology: Vancomycin & Cell Wall inhibitors cont'd

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Across
  1. 1. Daptomycin Clinical Applications: Recommended for treatment of severe infections caused by (blankorblank)
  2. 8. Vancomycin: Inhibits bacterial cell wall synthesis & (blank) polymerization
  3. 13. Bacitracin: (Two word blank) to mainly topical use
  4. 16. Daptomycin: (Blank) against Gram-negative bacteria
  5. 21. Vancomycin Clinical Applications: Given orally for the treatment of staphylococcal enterocolitis or antibiotic-associated pseudomembranous colitis (blank)
  6. 22. Vancomycin Clinical Applications: Treatment of Gram +ve infections in patients (two word blank) to beta-lactams
  7. 24. Vancomycin Resistance: Modification of the D-Ala-D-Ala binding site (D-Ala replaced by (Blank))
  8. 26. Vancomycin Clinical Applications: In combination with an aminoglycoside for empirical treatment of (two word blank)
  9. 27. Fosfomycin: Active against (blankandblank) organisms
  10. 29. Daptomycin PK: Elevated creatine phosphokinases (recommended to discontinue coadmin. of (blank))
  11. 30. Vancomycin: Bacterial (Blank)
  12. 32. Vancomycin PK: 90-100% excreted via (blank)
  13. 34. Vancomycin: Effective against multi-drug resistant organisms (eg, (blankblankblank))
  14. 37. Vancomycin: Virtually all (two word blank) organisms are intrinsically resistant
  15. 38. Daptomycin PK: (two word blank) only
  16. 39. Vancomycin Adverse Effects: (N-blank) (drug accumulation)
  17. 41. Daptomycin: Not effective in treatment of (blank)
Down
  1. 2. Daptomycin PK: Can (blank) in renal insufficiency
  2. 3. Daptomycin: Effective against resistant Gram-positive organisms (eg, MRSA, enterococci, (blankandblank))
  3. 4. Vancomycin Clinical Applications: Treatment of serious infections caused by (three word blank) Gram +ve organisms eg, MRSA
  4. 5. Daptomycin: Activity is (blank)
  5. 6. Fosfomycin: Oral administration. Used for treatment of (three word blank)
  6. 7. Vancomycin Adverse Effects: (Two word blank) eg, fever, chills, phlebitis at infusion site
  7. 9. Vancomycin: Active against (two word blank) bacteria only
  8. 10. Vancomycin PK: Requires slow IV infusion (blanktoblank minutes)
  9. 11. Vancomycin Resistance: (Two word blank) changes in drug permeability
  10. 12. Bacitracin: Interferes in late stage (three word blank)
  11. 14. Fosfomycin: Inhibits cytoplasmic enzyme (two word blank) in early stage of cell wall synthesis
  12. 15. Daptomycin MOA: Novel mechanism of action that is useful against (three word blank) bacteria
  13. 17. Vancomycin Adverse Effects: ‘Red man’ or ‘red neck’ syndrome ((Three word blank) over face and upper torso)
  14. 18. Bacitracin: Unique mechanisms so no (two word blank)
  15. 19. Daptomycin Clinical Applications: Treatment of complicated (three word blank) caused by susceptible S.aureus
  16. 20. Vancomycin PK: Penetrates CSF when (blank)
  17. 23. Vancomycin Clinical Applications: In combination with an (blank) for treatment of enterococcal endocarditis or PRSP
  18. 25. Bacitracin: (Two word blank) against Gram-positive organisms
  19. 28. Daptomycin MOA: Results in depolarization of cell membrane with (two word blank) to cell death
  20. 31. Daptomycin PK: (blank), nausea, headache, insomnia
  21. 33. Vancomycin Adverse Effects: (O-blank) (drug accumulation)
  22. 35. Daptomycin MOA: Binds to cell membrane via (two word blank) insertion of lipid tail
  23. 36. Vancomycin PK: (Two word blank) absorption
  24. 40. Vancomycin: Binds to the (blank) terminus of nascent peptidoglycan pentapeptide