Pharmacotherapy of Diabetes Crossword Puzzle

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Across
  1. 1. TZDs commonly cause fluid retention leading to ______ failure risk
  2. 6. GLP-1 receptor agonists slow ______ emptying
  3. 9. GLP-1 drugs slow gastric emptying leading to increased ______
  4. 12. Common hematologic ADR of teplizumab
  5. 14. Monoclonal antibody used to delay onset of Type 1 diabetes
  6. 15. DPP-4 inhibitors increase endogenous levels of this hormone (abbrev.)
  7. 16. Pancreatitis is a serious ADR of this incretin-based drug class (2 words)
  8. 17. Insulin causes intracellular shift of this electrolyte → risk of ______
  9. 18. Brand name for dual incretin agonist approved for weight loss
  10. 20. Ultra-long acting (>40 hrs) insulin
  11. 23. Injection-site fat changes
  12. 27. SGLT2 inhibitors promote weight loss through urinary loss of this substance
  13. 28. History of this pancreatic condition is a major precaution/contraindication for GLP-1 drugs
  14. 30. Major ADR of sulfonylureas due to excessive insulin release
  15. 31. Class that blocks K⁺/ATP channels to increase insulin secretion
  16. 33. Teplizumab increases this regulatory immune cell population (abbrev.)
Down
  1. 2. Dual incretin agonist used for both diabetes and weight loss
  2. 3. Serious but rare ADR of metformin (2 words)
  3. 4. Only insulin used IV
  4. 5. Major ADR of SGLT2 inhibitors involving genital area_____infections
  5. 7. Long-acting, peakless basal insulin
  6. 8. Alpha-glucosidase inhibitors cause this common GI symptom
  7. 10. Mechanism of teplizumab: binds CD3 receptor on ______
  8. 11. TZDs act on this nuclear receptor (PPAR-____)
  9. 13. Primary MOA of metformin: activation of ______-activated protein kinase
  10. 19. SGLT2 inhibitors increase urinary glucose leading to ______
  11. 21. Personal or family history of medullary thyroid carcinoma (MTC) is a contraindication with this class of drug
  12. 22. Intermediate acting, cloudy insulin
  13. 24. This class of drugs used for diabetes causes weight gain
  14. 25. GLP-1 receptor agonist brand specifically approved for chronic weight management (semaglutide)
  15. 26. Common ADR of GLP-1 receptor agonists (GI-related)
  16. 29. Sulfonylureas bind this receptor on β-cells (abbrev.)
  17. 32. Inhaled insulin