Across
- 3. Administration at a constant rate independent of concentration
- 5. Principle that Cp_ss increases linearly with infusion rate
- 8. Cl/F term used when infusion is through controlled-release oral delivery
- 10. Plasma level achieved when input equals output (Cp_ss)
- 13. Mathematical expression describing rise of Cp toward steady state
- 14. Patient-specific clearance estimated from observed Cp_ss
- 15. Constant rate of drug input, k₀
- 16. Amount given initially to achieve target concentration quickly
- 17. Desired plasma concentration window for a drug
- 18. Rule for adjusting infusion rate based on Cp_ss ratios
- 20. Time for Cp to fall by 50% or rise halfway toward steady state
Down
- 1. Principle that Cp_ss decreases when clearance increases
- 2. Clearance used to determine steady-state concentrations
- 4. Equation used to calculate Cp before steady state is reached
- 6. Time at which infusion stops (T)
- 7. Time required to reach 95% of Cp_ss (≈ 4.3 half-lives)
- 9. Plasma concentration at termination of the infusion
- 11. Monoexponential decline in Cp after infusion termination
- 12. Measuring Cp during steady state to individualize dosing
- 19. Elapsed time after stopping infusion (t′)