pkchp12

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Across
  1. 3. Rate of administration for multiple doses (Ra = dose/τ)
  2. 4. Narrow window requiring precise peak/trough control
  3. 6. Changing dose or interval to meet therapeutic targets
  4. 9. Plasma concentration just before the next dose (Cmin)
  5. 13. Total time measured from the first dose: (n-1)τ + t
  6. 14. Determines degree of accumulation and fluctuation
  7. 16. Giving repeated discrete drug doses over time
  8. 17. Increased frequency (shorter τ) reducing fluctuation but increasing accumulation
  9. 18. Time between doses (the dosing interval)
  10. 20. Ratio or spread between peak and trough concentrations
  11. 23. Situation where long t½ and short τ produce large buildup
  12. 25. Trough concentration before steady state (Cmin,n)
  13. 27. Concentration at a given time during the dosing interval, Cp(t)
  14. 28. Concentration window for safe and effective therapy
  15. 29. Principle that total concentration equals sum of contributions from each dose
  16. 30. Dosing design targeting specific steady-state peak and trough
Down
  1. 1. Condition where peak-trough pattern repeats with each dosing interval
  2. 2. First-order decrease in concentration between doses
  3. 5. Relationship where τ relative to t½ controls fluctuation
  4. 7. Within-interval time variable t that resets to zero each new interval
  5. 8. Initial dose used to reach steady-state levels more rapidly
  6. 10. Average plasma concentration at steady state
  7. 11. Plasma concentration immediately after a dose (Cmax)
  8. 12. About 4.3 half-lives are needed to reach 95% steady state
  9. 15. Two elements defining a multiple-dose regimen
  10. 19. Dosing design targeting a desired average steady-state concentration
  11. 21. Ratio comparing steady-state to single-dose exposure (r)
  12. 22. Trough at steady state (Cmin,ss)
  13. 24. Peak at steady state (Cmax,ss)
  14. 26. Increase in plasma concentrations with each dose until steady state