Across
- 4. First-order rate constant k governing drug decay
- 6. Example of drugs commonly dosed using intermittent IV infusions due to toxicity risk
- 7. Using Cp data to calculate individualized infusion rate
- 8. Repeated short-duration IV drug input rather than continuous infusion
- 11. Plasma concentration at the end of the infusion (Cmax)
- 16. Time between the start of successive infusions (tau)
- 17. Steady-state peak plasma concentration
- 18. Average rate of drug input across dose + interval
- 22. Parameter needed to compute peaks and troughs from infusion equations
- 23. Duration of each infusion period (t_inf)
- 25. Using log–linear slope from two concentrations to estimate k
- 26. Condition where peaks and troughs repeat each interval
- 28. Clock time just before next infusion begins
- 29. Drugs requiring precise control of peak and trough values
- 30. Total concentration equals the sum of contributions from all prior doses
Down
- 1. Measuring Cp to individualize intermittent-infusion dosing
- 2. Using desired peak/trough ratio to determine correct dosing interval
- 3. Increase in drug concentrations with each dose until steady state is reached
- 5. Plasma concentration just before the next infusion (Cmin)
- 9. Using Cp at a known time plus half-life to estimate peak and trough
- 10. Time required for plasma concentration to decline by 50%
- 12. Clock time at which the peak concentration occurs (end of infusion)
- 13. Difference or ratio between steady-state peaks and troughs
- 14. Zero-order input rate during the infusion (k0)
- 15. Time available for elimination (tau − t_inf)
- 19. Total time from therapy start: (n−1)tau + t
- 20. Concentration at time of infusion termination
- 21. Modifying dose when observed peaks or troughs miss targets
- 24. Steady-state trough plasma concentration
- 27. Concentration at any time during steady-state dosing