pkchp2

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Across
  1. 1. Transporter superfamily responsible for facilitated diffusion uptake.
  2. 4. Membrane surface facing the gut lumen or external environment.
  3. 8. Drug passage through epithelial cells.
  4. 9. Drug passage between epithelial cells.
  5. 10. Projections in the intestine that enlarge absorptive area.
  6. 11. Uptake transporter family for organic cations.
  7. 16. Protein that moves drugs into cells along gradient.
  8. 19. Criteria predicting poor passive permeability when ≥2 rules violated.
  9. 20. Equation describing passive diffusion rate across membranes.
Down
  1. 2. Difference in unbound drug concentration across a membrane.
  2. 3. Protein that moves drugs out of cells, often reducing absorption.
  3. 5. Dual‐layer membrane structure forming the barrier for absorption.
  4. 6. Transporter superfamily responsible for ATP-dependent efflux.
  5. 7. Efflux transporter family aiding renal excretion.
  6. 12. Brush-border structures that increase intestinal surface area.
  7. 13. Ability of a drug to cross a membrane.
  8. 14. Membrane surface facing the blood side.
  9. 15. Uptake transporter family for organic anions.
  10. 17. Major efflux transporter (P-glycoprotein/MDR1) reducing absorption or CNS entry.
  11. 18. Movement of drug across membrane down its concentration gradient.