Platelet Functions and Disorders

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Across
  1. 1. Acronym; GPIb/IX/V binds to _____ that is immobilized in collagen
  2. 3. GPIIb/IIIa binds to free _____________ and vWF
  3. 4. Term used to describe thrombocytosis secondary to acute hemorrhage
  4. 6. Cell type in which vWF is present (in addition to endothelial cells)
  5. 7. P2Y and P2Y12 bind to _______ receptors (two possible answers, either is correct)
  6. 10. Form of platelet granule that contains ADP/ATP, Serotonin, Calcium, and Receptors
  7. 13. Syndrome in which platelets lack dense granules
  8. 15. Shortened; dog breed most commonly associated with Type I vWD
  9. 16. Form of hemostasis in which the platelet plug is stabilized
  10. 17. Form of hemostasis characterized by platelet plug formation
  11. 19. Contraction of this organ can result in a physiologic thrombocytosis
  12. 20. Acronym used to characterize the primary mechanisms of thrombocytopenia
Down
  1. 1. Roman numeral; coagulation factor that is stabilized by vWF
  2. 2. Term used to describe a condition in an animal with superficial bleeding, normal platelet count, and abnormal platelet function
  3. 5. Acronym; test used to measure primary hemostasis and platelet function. Can only be performed in a patient with normal RBC and Platelet counts
  4. 8. In addition to nitric oxide, inhibits platelet activation and aggregation
  5. 9. Form of thrombocytopenia found in CKCS; patients with this condition still have an adequate platelet mass
  6. 11. Form of hemostasis in which fibrinolysis occurs
  7. 12. GPIa/IIa and GPIV bind directly to exposed...
  8. 14. Enzyme associated with outward expression of phosphatidylserine and phosphatidylethanolamine
  9. 18. Form of platelet granule that contains adhesive proteins, growth modulators, and coagulation factors
  10. 21. Acronym; most common cause of utilization thrombocytopenia