Plecanatide

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Across
  1. 2. :messenger that plays a role in the treatment of constipation (Abbreviation 4 letters)
  2. 4. : only FDA-approved structural analog of human uroguanylin (11 letters)
  3. 6. : is a condition characterized by infrequent and difficult bowel movements without an identifiable medical cause(Abbreviation 3 letters)
Down
  1. 1. : Plecanatide mimics this natural gut peptide (11 letters)
  2. 3. : Transmembrane receptor that regulates fluid and electrolyte. (Abbreviation 3 letters)
  3. 5. :A subtype of IBS where constipation is the predominant symptom. (Abbreviation 3 letters)