Preformulation

2. Predictions of stability or solubility which depend on particular _ _ _ _ form
4. Substance that absorbs sufficiently water to dissolves completely
6. a stage of development during which the physicochemical properties of drug substance are characterized
7. These properties are likely to change during process development
8. Ration of unionized drug distributed between the organic & inorganic aqueous phase at equilibrium
10. Properties of drug that drug can affect bulk & physicochemical properties
11. Reactio in which heat of solution is negative
13. Substance that forms hydrate addition of water at specific rate

1. As compared with the dry form, the degradation is much rapid in this form
3. Amorphous forms have higher than corresponding crystalline forms
5. process of increasing the solubility of a drug by addition of a third agent
9. Is the ability of a compound to crystallize as more than one distinct crystalline species with different internal lattice
12. This form materials are less stable than their crystalline forms.