Prophylaxis of Stroke

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Across
  1. 2. can be administered instead of warfarin in low risk patients
  2. 5. not a US AF warfarin trial
  3. 7. necessary for blood clotting
  4. 9. primary composite endpoints of ROCKETAF and RELY
  5. 10. prevents prothrombin from being converted to thrombin
  6. 11. the SPAF1 trial showed the annual rate of stroke was similar for patients with paroxysmal and ______AF
  7. 12. 2c9 is part of this enzyme superhighway
  8. 14. increased pressure in a confined anatomic space adversely affecting circulation
  9. 15. pradaxa is an oral _____
Down
  1. 1. in the common pathway and includes factors I, IIa and fibrin among others
  2. 3. dabigatran is a substrate of _____
  3. 4. head and shoulders safety
  4. 5. a measurement of renal function
  5. 6. prothrombin time (PT) measures the activity of the ___________pathway
  6. 8. indicated for AF with embolization but used primarily when oral anticoagulation must be interrupted for surgery Unfractionatedheparin
  7. 13. branded generic warfarin