Prophylaxis of Stroke!

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Across
  1. 2. Prothrombin time (PT) measures the activity of the ___________pathway
  2. 4. Dabigatran is a substrate of _____
  3. 5. Branded generic warfarin
  4. 6. Not a US AF warfarin trial
  5. 7. The SPAF1 trial showed the annual rate of stroke was similar for patients with paroxysmal and ______AF
  6. 10. Primary composite endpoints of ROCKETAF and RELY
  7. 12. Can be administered instead of warfarin in low risk patients
  8. 14. A measurement of renal function
  9. 15. Pradaxa is an oral _____
Down
  1. 1. In the common pathway and includes factors I, IIa and fibrin among others
  2. 3. Head and shoulders safety
  3. 6. 2C9 is part of this enzyme superhighway
  4. 8. Necessary for blood clotting
  5. 9. Indicated for AF with embolization but used primarily when oral anticoagulation must be interrupted for surgery
  6. 11. Increased pressure in a confined anatomic space adversely affecting circulation
  7. 13. Prevents prothrombin from being converted to thrombin