Across
- 1. is an undesirable association of partially unfolded proteins that may trigger immune responses.
- 7. covalent bond is formed between two cysteine residues that play a key role in stabilizing tertiary and quaternary structures.
- 8. bond between carbonyl oxygen and amide hydrogen stabilise α-helices and β-sheets.
- 10. interaction is the dominant stabilizing force in protein tertiary structure resulting from burial of non-polar residues away from water.
Down
- 2. is chemical degradation initiated by free radicals.
- 3. Disulfide exchange is formation of incorrect covalent S–S bonds between ..... residues
- 4. is the cleavage of peptide or amide bonds caused by nucleophilic attack of water.
- 5. is the conversion of an amino acid into a different stereochemical form due to rearrangement around a chiral α-carbon.
- 6. is a degradation pathway involving hydrolysis of amide side chains of Asn or Gln leading to changes in protein charge.
- 9. is the only amino acid lacking a chiral α-carbon and therefore incapable of stereochemical isomerisation.