Proteins

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Across
  1. 2. main protein in microtubules
  2. 5. proteins that attach to the actin cytoskeletal filaments to zip two cells together
  3. 6. proteins that block the diffusion of large molecules but do not prevent the passing of small molecules
  4. 9. protein complex that causes mitosis (prophase) to start by phosphorylating condensin
  5. 12. protein that leaves the nucleus, opposite of importin
  6. 13. Gef for ran, resides in the nucleus, puts GTP on RAN to activate it and separate the importin from the cargo protein.
  7. 14. protein that is phosphorylated by MPF and organizes the DNA to maintain a condensed state
  8. 16. a protein that helps maintain mechanical stability within the cell, and are often found in the cytoskeleton of epithelial cells
  9. 19. forms a helix around the mitochondrion during mitochondrial fission
  10. 22. type of GTPase that carries and releases cargo into the nucleus.
  11. 23. proteins in the kinetochore that monitor chromosome-microtubule attachments and activate APC (confirm every chromosome if bi-oriented and under tension)
  12. 25. protein that detects and binds to damaged DNA, which leads to the phosphorylation of p53
  13. 26. GEF protein that activates RAS by adding GTP on it
  14. 27. motor protein in the cytoskeleton that transports cargo along microtubules
  15. 28. proteins that become hydrated and make a gel matrix which the collagen and elastin embed in
  16. 32. GAP for RAN, resides in the cytoplasm, hydrolyzes the GTP faster so RAN releases the importin so the cycle can repeat
  17. 34. tiny proteins that signal for a proteasome to destroy it
  18. 35. molecular chaperone in the ER that regulates intracellular processes and is similar to calnexin
  19. 37. transmembrane proteins that make up connexons and pull cells together
  20. 38. proteins that transport cargo proteins into the nucleus once they activate the nuclear localization signal (NLS).
  21. 40. proteins that bind to GTP and hydrolyze it to make GDP.
Down
  1. 1. motor protein that depend on ATP to move cargo along microtubules
  2. 3. structure on the outer surface of the centromere that is made of 100 different proteins.
  3. 4. molecular chaperone in the ER that ensure that misfolded proteins are not secreted in N-linked glycosylation
  4. 7. gene that is mutated in about half of all tumors
  5. 8. protein that holds the two sister chromatids together. In prophase, it is concentrated in the centromere
  6. 10. proteins in the outer mitochondrial membrane that allow moderately sized molecules to flow freely from the cytoplasm into the intermembrane space
  7. 11. ER chaperone that binds to unfolded ER proteins to give them a chance to fold properly
  8. 14. transmembrane protein that help tight junctions control the flow of molecules intracellularly
  9. 15. a protein that inhibits separase to ensure it does not constantly cleave cohesin proteins. It is tagged with a ubiquitin protein and degraded by a proteasome to allow separase to cleave cohesin.
  10. 17. a protein that is part of the GTPase family, and acts as molecular scissors for vesicles being imported from the plasma membrane
  11. 18. proteins that attach extracellular matrix directly to the cells. Examples: fibronectin and laminin
  12. 20. protein with an SH2 domain that binds to activated receptor kinase
  13. 21. intermediate filaments that are part of the cytoskeleton and provide mechanical support for the envelope. Three types: A, B, C.
  14. 24. a protein complex that allow dynein to bind to organelles moving across microtubules
  15. 29. protein in extracellular matrix. Allows tissue to be elastic/flexible. Can go back and forth between two conformations
  16. 30. most abundant protein in vertebrates
  17. 31. motor protein in actin filaments that helps facilitate movement and muscle contraction in muscle cells
  18. 32. A small monomeric G protein that is activated by a growth factor and kicks off a phosphorylation cascade that ultimately leads to cell division
  19. 33. a cytosolic protein that is made by free ribosomes
  20. 36. proteins that help reshape cell walls by disrupting bonding in cellulose fibers
  21. 37. Hollow, barrel shaped proteins that provides a space where new proteins can fold properly
  22. 39. protein kinase that is involved in the Ras-Map pathway and is activated by Ras-GTP
  23. 41. MAP protein that promotes tubulin assembly and polymerization