Proteomics Milestone Crossword Puzzle

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Across
  1. 1. Swedish-based program launched in 2003 with the aim to map all the human proteins in cells,
  2. 8. ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) In 1984 and 1985 respectively
  3. 10. the Australian scientist coined the terms Proteome and proteomics in 1994 and 1996 respectively.
  4. 11. Associates developed ALC100 HPLC the first commercial HPLC in 1967
  5. 13. and Alan Waggoner invented
  6. 17. are variants of genetically encoded proteins and the lexicon was coined in 2013.
  7. 18. Aston, and Dempster developed the first mass spectrometry in 1897 and 1919.
  8. 19. and klose independently developed 2D Gel electrophoresis technique in 1975.
  9. 20. University established the first Proteomics Lab in 1995.
  10. 23. and Hillenkamp and Karas developed
  11. 24. and his team developed the first microarray Chip for Complete Analysis of Proteins in 2001
  12. 26. technology limited developed AlphaFold in 2018 which was awarded the Nobel Prize in 2024.
Down
  1. 2. and his student developed the quadrupole mass analyzer and the 3D quadrupole ion trap in 1953.
  2. 3. coined the term ‘Protein’ in 1838.
  3. 4. and his team performed the first single cell proteomics analysis in Xenopus laevis egg in 2014
  4. 5. from University of Pennsylvania developed the first TOF-MS in 1946
  5. 6. was launched by HUPO in 2011 to Map the entire human proteome
  6. 7. determined the complete amino acid sequence of insulin in 1952
  7. 9. Swedish Biochemist developed the Edman degradation method in 1950
  8. 11. Swiss Chemist developed NMR methods to map the 3D structure of proteins in mid 1980s
  9. 12. a American Biochemist and his team conceptualized Data Independent Acquisition in 2003
  10. 14. researcher from France and his team developed the in-gel digestion method of proteins for internal sequence analysis in 1992.
  11. 15. and his team reported the SRM/MRM mass spectrometry technique in 1978.
  12. 16. the world's first next-generation single-molecule protein sequencing platform was launched by Quantum-Si in 2022
  13. 17. and Kendrew used X-ray crystallography to determine the atomic structures of proteins in 1962
  14. 21. Biosciences is credited to develop spatial proteomics method, which has won the method of the year award by Nature Methods in 2024.
  15. 22. , Fenn and Wüthrich developed soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules in 1987.
  16. 25. DIGE in 1997