Pulmonary Puzzler: A Pharmacy Student's Review of Asthma and COPD

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Across
  1. 3. Anti-IL5 that is dosed subcutaneously every 4 weeks for the treatment of severe asthma
  2. 5. Chronic obstructive pulmonary disease
  3. 6. Rinsing mouth after ICS use can prevent this complication
  4. 9. A patient experiences sudden severe wheezing and difficulty speaking. Where should the patient go?
  5. 10. IL-4 and IL-13R agent effective for many indications, including asthma, atopic dermatitis, nasal polyps, and esophagitis
  6. 12. Disease of airway inflammation and bronchial hyperresponsiveness
  7. 14. Blood biomarker useful in assessment of biologic initiation
  8. 17. Therapeutic target for tezepelumab
  9. 19. Brand name of mometasone and formoterol combination inhaler
  10. 23. Common LAMA used once daily
  11. 25. Therapeutic class of inhaled therapy to control inflammation
  12. 26. Biologic studied for use in COPD in trials NOTUS and BOREAS
  13. 27. Long-acting beta agonist used in SMART
  14. 28. Exposure/environmental risk factor for COPD progression
  15. 29. Orally administered PDE4 inhibitor that prevents cAMP breakdown to provide anti-inflammatory effects
  16. 32. Lung measurement of volume of air that can be exhaled in first second of foreceful exhale
  17. 37. Therapeutic class of beta agonists and muscarinic antagonists
  18. 39. Calling the pharmacy to ensure monthly refills of maintenance inhaler can ensure good ___________
  19. 40. Brand name of dupilumab
  20. 41. Neurotransmitter that causes bronchoconstriction, mucus secretion, inflammation, and airway remodeling
  21. 43. Public health measure that can be used to prevent common respiratory illnesses
  22. 44. Anti-IgE monoclonal antibody
  23. 45. First inhaled corticosteroid that demonstrated effectiveness and had few systemic side effects
  24. 47. Medical term for shortness of breath
  25. 49. Exhaled nitric oxide test which serves a way to determine amount of lung inflammation
Down
  1. 1. Active ingredient in ProAir, Proventil, and Ventolin inhalers
  2. 2. Patient with acute COPD flare in the ER needs nebulized anticholinergic
  3. 4. Leukotriene receptor antagonist with box warning for neuropsychiatric adverse events
  4. 7. Evidence-based recommendations used for the management of COPD
  5. 8. Route of administration for corticosteroids that has been linked to serious side effects such as immunosuppression, osteoporosis, diabetes mellitus, cataracts, and an increased risk of cardiovascular disease
  6. 11. Biologic agent that can be given every 8 weeks during the maintenance phase
  7. 13. Terminology for the standard care of COPD, including an inhaled corticosteroid, long-acting beta-agonist, and long-acting muscarinic antagonist
  8. 15. Pulmonary function test to measure how much air can be breathed in and out
  9. 16. Handwritten, printed, digital, or pictorial document to help patients assess their level of asthma control and instructions if suboptimal
  10. 18. Brand name of budesonide and formoterol combination inhaler
  11. 20. Maintenance treatment approach using a single inhaler for maintenance and reliever control
  12. 21. Most common pathogenic species in COPD
  13. 22. Imbalance in the pulmonary _________ in COPD patients may lead to increased infections
  14. 24. Antibiotic that can be used three times per week to reduce asthma exacerbations
  15. 27. Brand name of benralizumab
  16. 30. Minimum number of months needed to assess effectiveness of a biologic for asthma
  17. 31. Route of administration for biologics delivered at home
  18. 33. Inhaler type that requires patients to make a forceful and deep inhalation
  19. 34. Antibiotic commonly used for bacterial exacerbations starting with "D"
  20. 35. Tube-like device that attaches to a metered-dose inhaler to more effectively deliver asthma medication to the lungs
  21. 36. Brand name of penicillin compound commonly used for COPD exacerbations
  22. 38. Combination ICS/LABA starting with "A"
  23. 42. Next step add-on for patient on LAMA/LABA that still has exacerbations + high eosinophils
  24. 46. Subset of asthma characterized by eosinophilic airway inflammation
  25. 48. Anti-inflammatory reliever; treatment with low-dose ICS and formoterol taken whenever needed to relieve asthma symptoms