Across
- 2. A mucosal protective agent that forms a sticky, gel-like barrier over ulcer craters, requiring an acidic environment to activate.
- 5. The primary therapeutic response achieved in the airways by stimulating beta-two receptors or blocking muscarinic pathways.
- 7. An osmotic laxative that acidifies the colon to trap ammonia as ammonium, primarily used to manage hepatic encephalopathy.
- 9. A long-acting beta-two adrenergic agonist (LABA) with a rapid onset, routinely paired with an inhaled corticosteroid for maintenance.
- 11. A synthetic prostaglandin E1 analogue that stimulates gastric mucus secretion, strictly contraindicated in pregnancy due to abortifacient actions.
- 15. A mucosal protective subsalicylate compound that exerts antimicrobial effects against H. pylori, known for causing a benign black stool.
- 19. A foundational H2 blocker that acts as a potent inhibitor of multiple CYP450 enzymes, commonly causing significant drug interactions.
- 21. A neurokinin-one receptor antagonist that acts centrally in the brainstem to prevent delayed chemotherapy-induced emesis.
- 24. The physiological release of acid, pepsin, or mucus into the gastric lumen, heavily targeted by antiulcer pharmacotherapy.
- 25. A highly effective serotonin 5-HT3 receptor antagonist widely prescribed to prevent chemotherapy-induced nausea and vomiting.
- 26. A potent inhaled corticosteroid (ICS) utilized for long-term asthma control, requiring patients to rinse their mouth to prevent thrush.
- 27. A short-acting beta-two adrenergic agonist (SABA) utilized as emergency rescue therapy to reverse acute bronchospasm.
- 28. A bulk-forming laxative that absorbs water in the intestinal lumen to increase stool mass and mechanically stimulate peristalsis.
- 29. A prototypical proton pump inhibitor that irreversibly binds to the hydrogen-potassium ATPase pump in gastric parietal cells.
Down
- 1. A class of pharmacological agents that accelerate gastrointestinal motility by enhancing coordinated smooth muscle contractions.
- 3. A potent mucolytic agent that breaks disulfide bonds in respiratory mucus, also serving as the specific antidote for acetaminophen toxicity.
- 4. A combination of essential digestive enzymes administered orally with snacks and meals to patients with cystic fibrosis.
- 6. The functional receptor classification for drugs like famotidine, diphenhydramine, and ondansetron that work by blocking signaling.
- 8. A long-acting anticholinergic (LAMA) administered via inhalation for the maintenance treatment of chronic obstructive pulmonary disease.
- 10. A leukotriene receptor antagonist utilized for chronic asthma prophylaxis, carrying warnings for neuropsychiatric events.
- 12. A historical H2 receptor antagonist that suppresses gastric acid secretion, largely replaced by famotidine due to impurity concerns.
- 13. Nerve pathways or receptor responses that are targeted by anticholinergic medications to limit excessive broncho-secretion.
- 14. An expectorant agent that thins and loosens respiratory tract secretions, making a productive cough more effective.
- 16. An opioid receptor agonist that acts strictly on the intestinal smooth muscle to slow GI transit time without crossing the BBB.
- 17. A first-generation H1 antihistamine that readily crosses the blood-brain barrier, causing pronounced sedation and anticholinergic effects.
- 18. A prokinetic dopamine antagonist that stimulates upper GI motility, carrying a prominent black-box warning for tardive dyskinesia.
- 19. A second-generation H1 antihistamine with minimal central nervous system penetration, offering long-acting allergy relief with low sedation.
- 20. A hypersecretory phenomenon where stopping proton pump inhibitors abruptly causes a severe temporary surge in gastric acid production.
- 22. A phenothiazine antiemetic agent that blocks dopamine receptors in the CTZ, frequently causing extrapyramidal side effects.
- 23. A soluble theophylline salt complex with a narrow therapeutic index, requiring strict serum drug level monitoring to prevent seizures.