RNA Processing

Edit Answers
123456789101112131415161718192021222324252627282930313233343536373839404142434445
Across
  1. 3. Complex of snRNAs + snRNPs that mediates splicing
  2. 4. Post-transcriptional base changes (C→U, A→I, U insertions/deletions)
  3. 8. Enzyme adding adenines to RNA tail
  4. 9. >200 nt RNA that regulates gene expression
  5. 11. Minimal RNA modifications, unstable mRNAs
  6. 13. Synthetic mRNA used to induce immune response
  7. 15. Small ncRNA regulating gene expression (~22 nt)
  8. 17. Large ribonucleoprotein complex for rRNA processing
  9. 18. Eukaryotic transcript before capping, splicing, polyadenylation
  10. 21. Immature tRNA that requires trimming, CCA addition, modification
  11. 22. Modifications to precursor RNAs to make them functional
  12. 25. Enzyme adding RNA cap
  13. 30. Core catalytic protein in RISC
  14. 31. lncRNA silencing one X chromosome in females
  15. 33. Multi-protein complex that edits RNA
  16. 34. Modified tRNA base
  17. 35. Addition of 7-methylguanosine to RNA 5′ end
  18. 36. Small nuclear RNA involved in splicing (U1, U2, U4, U5, U6)
  19. 37. Enzyme that cleaves 5′ ends of pre-tRNAs
  20. 39. Chemical changes ensuring codon recognition accuracy
  21. 40. Pri-miRNA → Drosha → pre-miRNA → Dicer → mature miRNA
  22. 41. Determined by 5′ cap and 3′ poly-A tail length
  23. 42. Removal of introns and joining of exons
  24. 43. RNase III enzyme producing siRNAs and miRNAs
  25. 44. snRNA + proteins forming spliceosome units
Down
  1. 1. dsRNA-derived small RNA triggering degradation
  2. 2. Modified base found in tRNA and rRNA
  3. 5. Extensive RNA modifications in nucleus
  4. 6. TAR RNA-binding protein assisting Dicer in RNAi
  5. 7. Protein complex mediating RNAi
  6. 10. Movement of processed RNA from nucleus to cytoplasm
  7. 12. Proteins that recognize the 5′ cap
  8. 14. Gene silencing via siRNAs and miRNAs
  9. 16. Noncoding sequence removed from pre-mRNA
  10. 19. Protein synthesis using mRNA, tRNA, rRNA
  11. 20. Protein Protein binding poly-A tail for stability
  12. 23. Addition of poly-A tail to 3′ end of mRNA
  13. 24. Small nucleolar RNA guiding rRNA modifications
  14. 26. Enzyme that trims 3′ ends of pre-tRNAs
  15. 27. Coding sequence retained in mRNA
  16. 28. snoRNA + proteins; direct rRNA methylation/pseudouridylation
  17. 29. Newly made RNA that must be processed
  18. 32. Precursor of ribosomal RNA, processed into mature rRNAs
  19. 38. Process producing multiple proteins from one gene
  20. 45. III Enzyme cleaving dsRNA regions (prokaryotic rRNA processing)