ROMEO

4. Determines the presence of active anionic & cationic groups on the albumin to bind a variety of drug action
8. Active form of Enalapril and a potent hypertensive agent
11. Once the drug reaches this location, the drug will be carried out by the blood circulation to the different tissues of the body
12. Phase 1 is characterized as
17. A reaction of phase 1 in which a process of adding oxygen or removal of hydrogen and most important enzyme involved in this reaction ic CYP450
19. A protein bound drug is neither metabolized nor excreted hence it is pharmacologically inactive due to its _____ and pharmacodynamics inertness
20. The process by which drug diffuses or is transferred throughout the fluids and tissues of the body

1. It is related in protein binding wherein increasing of it will also result in increasing the extent of binding
2. A drug with sufficient concentration that can not be build up in the receptor site for action
3. A macromolecules which are particularly responsible for such an interaction
5. A product of drug metabolism that can retain the action as the parent drug
6. A type of drug that is only capable of being eliminated. Example of this is tetracycline which is eliminated mainly by glomerular filtration
7. It has highest concentration of drug metabolizing enzymes due to its location between GIT & the blood circulation
9. A protective biochemical process by which the bodies alter xenobiotics either enzymatically or non-enzymatically
10. Volume of distribution is the theoretical volume of fluid in which the amount of drug administered would have to be diluted to produce a concentration. What concentration it is?
13. A product of drug metabolism with no pharmacological activity of the original drug
14. Mechanism of action in binding of drugs to proteins
15. A process where enzymes or other biologically active metabolite would have biological activity
16. Inactive parent drug
18. Mechanism of action in binding of drugs to proteins which generally involves weak chemical bond