cryptic crossword

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Across
  1. 2. the vaccine for reliable lisps? (6)
  2. 5. search engine about singular northern city losing life (8)
  3. 6. world league topples domestic airline with jousting sticks (10)
  4. 9. part of eyebrow reckons to destroy (5)
  5. 14. a few insects looking to rent? (7)
  6. 15. pirate exclaims: standard procedure for bladder infection in the first (7)
  7. 16. snake talks about rotated circle for bobbins (6)
  8. 17. fasten parts backwards (5)
  9. 19. to paraphrase: "Its in the status quo, technically" (5)
  10. 20. intergalactical smuggler above british dynasty (7)
  11. 22. mixed gauge from local access network code (8)
  12. 28. fire and, initially not, colombia make up a spanish dance (8)
  13. 29. i can hear lynx on the golf course (5)
  14. 31. the final leaves fall to listen in (9)
  15. 32. arsenic is in deep bullshit (4)
  16. 33. little change seen in incentives (4)
  17. 34. sloppy predator is copied (8)
  18. 35. unmanageable vegetable* sliced to an unspecified amount (10)
  19. 36. take a nap then have a golden shout at a diner (10)
  20. 40. proofreader of a wild riot started by yorkist king (6)
  21. 42. sounds like my tea was less than half filled with seaweed (8)
  22. 43. igneous rock found amongst bathsalts (6)
Down
  1. 1. doctor hesitates, playing percussion on ancient vase (8)
  2. 3. pauper gamebird has no hotel (7)
  3. 4. the murderer is a bit sick; iller on the inside (6)
  4. 7. take a look as he hobbles into general electric (7)
  5. 8. continent bids adieu, roped into the midst of it (6)
  6. 9. wisconsin next to layer of fat around the district of columbia is unpredictable (8)
  7. 10. ruins shattered by scottish widows with broken cane (9)
  8. 11. question without its o is in regular anxiety (8)
  9. 12. imperial jewels are in deers, it yelped (5)
  10. 13. he discusses a pen and chops up vestigial organs (10)
  11. 17. overwhelming chant about parent (10)
  12. 18. eternal hair-do for a year on fantasy tree person (9)
  13. 21. messed-up sister, alternatively, doesn't allow current to pass (8)
  14. 23. botched scalp dislodged from within, died (9)
  15. 24. conservative instead of weirdly hot personal secrets being revealed online (8)
  16. 25. almost fiery bondage follows eastern european (7)
  17. 26. greek snacks manage with spinning gadgets (9)
  18. 27. closer to her maiden name, abnormal rear (6)
  19. 30. grannies and conferences are on the steps? (6)
  20. 37. spreadsheets standout (5)
  21. 38. beginning of biblical book feels nothing (4)
  22. 39. together, dictator in a milligram is calculating (9)
  23. 41. breaks between bursts (10)