Severe Combined Immunodeficiency

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Across
  1. 6. Lymphocyte type profoundly deficient or non-functional in all SCID forms
  2. 7. Diagnostic test enumerating lymphocyte subsets (T, B, NK cells)
  3. 8. Persistent oral candidiasis, a frequent early clinical sign
  4. 10. Essential pre-treatment for blood products to prevent GVHD
Down
  1. 1. Type of infection caused by organisms that usually don't harm healthy immune systems
  2. 2. Life-threatening lung infection, frequently caused by Pneumocystis jirovecii
  3. 3. Antibody-producing cells, often present but non-functional without T cell help
  4. 4. Treatment aiming to correct the underlying genetic defect
  5. 5. Most frequent inheritance pattern, often due to IL2RG mutation
  6. 6. Organ essential for T cell development, often rudimentary in SCID
  7. 9. Complication from non-irradiated transfusions or maternal T cells (abbr.)
  8. 11. Supportive therapy providing passive immunity via pooled antibodies (abbr.)