Severe Combined Immunodeficiency

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Across
  1. 3. Antibody-producing cells, often present but non-functional without T cell help
  2. 4. Organ essential for T cell development, often rudimentary in SCID
  3. 6. Lymphocyte type profoundly deficient or non-functional in all SCID forms
  4. 9. Essential pre-treatment for blood products to prevent GVHD
  5. 10. Life-threatening lung infection, frequently caused by Pneumocystis jirovecii
  6. 11. Universal testing of infants using TRECs assay for early SCID detection
  7. 13. Complication from non-irradiated transfusions or maternal T cells (abbr.)
  8. 14. Molecular byproducts measured in newborn screening to assess T cell production (abbr.)
Down
  1. 1. Type of infection caused by organisms that usually don't harm healthy immune systems
  2. 2. Diagnostic test enumerating lymphocyte subsets (T, B, NK cells)
  3. 5. Most frequent inheritance pattern, often due to IL2RG mutation
  4. 7. Persistent oral candidiasis, a frequent early clinical sign
  5. 8. Treatment aiming to correct the underlying genetic defect
  6. 9. Supportive therapy providing passive immunity via pooled antibodies (abbr.)
  7. 12. Genes crucial for V(D)J recombination; defects cause a form of AR SCID (abbr.)