Across
- 2. VEGF is an important _______ which plays a major role in angiogenesis.
- 5. Intracellular receptors ideally require a _______ molecule in nature which is able to penetrate the cell membrane.
- 8. ______ are a specific form of ligand and act as brain chemicals that communicate through the brain and body.
- 11. The retinoic acid receptor is a nuclear ______ receptor which also functions as a transcription factor.
- 12. the NO/cGMP/PKG signaling pathway is important to ______ intracellular calcium levels to allow smooth muscle relaxation.
Down
- 1. NO is synthesized from L-arginine in the ______ cells upon rise in Ca2+.
- 2. G protein gets activated upon binding of _____ to its alpha subunit.
- 3. A second receptor know as receptor ______ can also activate IP3.
- 4. The integral membrane proteins of ______consist of seven membrane-spanning helices.
- 6. The amino acids that line the inside of the ion channel are ______ to allow for the passage of water or ions.
- 7. The addition of a phosphate group to serine/threonine residue leading to phosphorylation is initiated by _______ proteins.
- 9. Phospholipase C activates _______ which in turn activates PKC.
- 10. ______ is synthesized from ATP upon activation of Adenylyl Cyclase.