SLE334 Lecture 21 (congenital and CNS)

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Across
  1. 2. ______ behavious in people with encephalitis. also seizures, , nausea, vomiting, fever
  2. 3. many congential infections diagnose by detection of antigens/antibodies in infant ____ _____. eg CMV and rubella and toxoplasmosis
  3. 8. type of meningitis caused by organism that commonly infects lungs (causing granulomas) onset over a few weeks. tubercules form in brain when miliary (spreading) _____ occurs
  4. 9. blood-___________ barrier invasion can cause encephalities (brain inflammation)
  5. 11. ___________ and botulinium toxins act on NS without directly affects CNS
  6. 13. ____bodies in neurons of person with rabies
  7. 14. _____ pneumoniae is a common cause of meningitis in kids and elderly.
  8. 15. puerperal _____ aka "childbed fever". back in the day when trainee doctors didnt wash hands after touching cadavers... highly prevantable.
  9. 16. as well as causeing birth defects/deaths this bacteria (found in cheeses) can also cause meningitis in immunocompromised people
  10. 18. neonatal septicemia often progresses to ________ (infla,mmation of brain lining)
  11. 19. infant infection with ______ __________ virus (ulcerating vescicles in mother) should be considered in a baby who is ill after a few weeks after birth
  12. 24. ingestion of listeria can lead to fetal ____ or malformations. treatment via ampicillin. no vaccine
  13. 26. this infection within first 3 months of proegnancy is often unnoticed in mama. PREVENTABLE by vaccination. affects eye, heart, brain and ear. MENTAL RETARDATION AND DEAFNESS later in childhood
  14. 27. hormondal changes in pregnancy can ___________ certain infections
  15. 30. _____ within mothers womb is susceptible for 3 reasons: NO IgG is produced. IgM and IgA only produced a little bit. Cell mediates and cytokine defences are poorly developed/not there.
  16. 31. this virus is caused mainly by primary infection of mother, though can be due to reactivation of prev. aquired virus. vaccination prior to pregnancy. enlarged liver and spleen of child, retardation, eye and ear defects
  17. 32. rabies, herpes and varicella-zoster (chickenpox/shingles) viruses can invade the CNS via _____________ nerves.
  18. 33. meningitis in infants/kids commonly caused by h influenzae which has a polysaccharide ________ as a virulence factor
Down
  1. 1. eye infection occuring around time of birth. more drastic than chlamydia
  2. 4. MOST COMMON CAUSE OF MENINGITIS. milder than bacterial meningitis. diagnosed by PCR of CSF
  3. 5. rhabdovirus in saliva of infected animals. causes encephalitis. negri bodeis in neurones
  4. 6. microbes can cross barriers by being carreid across by infected ____ blood cells
  5. 7. common cause of mild encephalitis (causes swollen neck glands Paraotitis)
  6. 8. caught by cat feces. often no detectable malformations at birth. no vaccine. avoidance of meat, cat poo.
  7. 10. blood-______________ barrier invasion can cause meningitis (inflamm of brain lining)
  8. 12. ___ encephalitis (HSE) most common cause of severe actue sporaddic encephalitis
  9. 13. stiffness of the ___ is a common symptom of meningococcal infection causing meningitis. often hemorhagic skin rash (infects systemically)
  10. 17. virus transmitted to 25% of babies by ___ positive mother. one third infected in utero, rest infected at time of birth. develop AIDS by 1 year
  11. 20. inflammation of brain usually caused by viruses. herpes simplex virus most common cause of severe acute sporadic __________
  12. 21. this immunoglobulin is not produced by fetus in utero
  13. 22. causes encepalitis and paralysis when invades CNS. very uncommon in rish countries. starts with P
  14. 23. infections that harm baby in womb often ____ in mother
  15. 25. percentage of population carrying neissseria menindigitis that causes meningitis.
  16. 28. __________ (present at time of birth) infections include: CMV, rubella, toxoplasmosis, HIV, listeriosis
  17. 29. this type of cell increases in CSF when infection occurs