Spironolactone-MRA

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Across
  1. 3. Typical once-daily frequency abbreviation
  2. 7. counseling:avoid high-potassium
  3. 8. contraindications:severe_impairment
  4. 10. diuretic class often paired in resistant edema
  5. 11. take to improve absorption/reduce GI upset
  6. 15. indication with peritoneal fluid; common in cirrhosis
  7. 16. competitive blocker of this receptor family
  8. 17. site of action:nephron segment for aldosterone-sensitive NA+ reabsorption
  9. 18. typical adult HF dose range per day
  10. 19. electrolyte to monitor closely
  11. 20. pharmacologic role at receptor:competitive
  12. 21. kidney function abbreviation
  13. 22. longer-acting selective MRA comparator with lower gynecomastia risk
  14. 23. key cation spared by the drug
Down
  1. 1. HF/HTN monitoring
  2. 2. portal hypertension complication indication:peritoneal fluid
  3. 4. amount per intake
  4. 5. drug class of Spironolactone
  5. 6. hormone whose effects are antagonized
  6. 9. timing tip to reduce nocturia:take in the
  7. 12. endocrine adverse effect risk:elevated blood potassium
  8. 13. medication class that may blunt diuretic effect and raise K+
  9. 14. breast-related adverse effect, dose-related in men
  10. 15. off-target receptor family contributing to sexual/endocrine AEs