Statins: Hard

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Across
  1. 5. Variation in genes affecting metabolism
  2. 7. Major protein in LDL particles
  3. 10. Study of statin absorption and clearance
  4. 11. May influence statin tolerance
  5. 13. Reduced by statins possibly causing fatigue
  6. 15. Receptor upregulated by statin therapy
  7. 16. Strategy after muscle side effects
  8. 18. Therapy statin plus ezetimibe or fibrate
  9. 19. Transcription factor increased by statins
  10. 20. The type of cardiovascular disease statins prevent
Down
  1. 1. Type of statins with lower muscle penetration
  2. 2. Study of statin effect on lipids
  3. 3. Life longer in rosuvastatin than simvastatin
  4. 4. Pass describes liver metabolism of oral statins
  5. 6. Liver cells where statins exert main effect
  6. 8. Type of statins with more CNS penetration
  7. 9. Gene variant linked to myopathy risk
  8. 12. Cholesterol made inside the body
  9. 14. Intermediate blocked in cholesterol pathway
  10. 17. Statins also reduce this beyond lipid lowering