Stress

4. excessive or stressful demands, imagined or real, made on an individual to think, feel, or act in particular ways
8. drained of one's physical or mental resources
10. easily agitated or alarmed
12. irritating inconvenience
14. mental or emotional strain.

1. deep sorrow, especially that caused by someone's death
2. subject to aggressive pressure or intimidation.
3. the state of undergoing pain, distress, or hardship
5. a deeply distressing or disturbing experience.
6. a load, typically a heavy one
7. slightly angry; irritated
9. a state of worry or mental tension caused by a difficult situation
11. a severe or excessive demand on the strength, resources, or abilities of someone or something.
13. give way to anxiety or unease; allow one's mind to dwell on difficulty or troubles