Transdermal Drug Delivery System (TDDS)

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Across
  1. 3. Covering the skin to reduce water loss and increase drug penetration.
  2. 8. The initial entry of a drug into the stratum corneum.
  3. 9. Movement of a drug through the skin layers into systemic circulation.
  4. 12. Uses ultrasound waves to enhance drug permeation through skin.
  5. 14. The passive movement of drug molecules from higher to lower concentration.
  6. 15. A TDDS design where the drug is uniformly dispersed in a polymer layer.
Down
  1. 1. Tiny projections that create micro-channels in skin to improve absorption.
  2. 2. Corneum The outermost skin layer and primary barrier to drug absorption.
  3. 4. Drug property that determines its ability to dissolve in skin lipids.
  4. 5. Technique using a small electrical current to drive drugs across skin.
  5. 6. The flat medicated system applied to skin for controlled drug delivery.
  6. 7. Release A mechanism ensuring steady drug levels over an extended period.
  7. 10. A TDDS design with a drug compartment separated by a membrane controlling release.
  8. 11. A chemical or physical method used to increase skin permeability.
  9. 13. The sticky layer ensuring the patch stays in contact with the skin.