Across
- 2. : Works with BRCA1 to recruit RAD51 and stabilize DNA repair complexes.
- 3. : Mismatch repair protein; its loss leads to microsatellite instability in Lynch syndrome.
- 5. : Hypoxia-inducible transcription factor that upregulates GLUT1 and transferrin receptor under low oxygen.
- 6. : Pro-apoptotic Bcl-2 family member that promotes cytochrome c release from mitochondria.
- 8. : Matrix metalloproteinase that degrades extracellular matrix and promotes invasion.
- 10. : Vascular endothelial growth factor; stimulates angiogenesis in tumors.
- 12. : Pro-apoptotic protein inhibited when phosphorylated by Akt and bound by 14-3-3.
- 13. : Serine/threonine kinase activated by PI3K signaling that promotes survival by phosphorylating Bad.
- 15. : Glucose transporter upregulated by HIF-1α in glycolytic cancer cells.
- 17. : DNA recombination protein that forms filaments on single-stranded DNA during homologous recombination.
- 18. : Transmembrane receptor mediating cell–matrix adhesion and intracellular signaling.
Down
- 1. : Anti-apoptotic protein that inhibits mitochondrial membrane permeabilization.
- 3. : Partner of MSH2 in mismatch repair of single-strand mismatches.
- 4. : Partner of HIF-1α forming the active heterodimeric transcription factor regulating glycolysis genes.
- 7. : Kinase that senses double-strand DNA breaks and triggers p53 activation and DNA repair checkpoints.
- 9. : Tumor suppressor phosphatase that inhibits the PI3K/AKT pathway by dephosphorylating PIP3.
- 11. : Focal adhesion kinase linking integrins to the actin cytoskeleton and promoting cell migration.
- 12. : A gene mutated in hereditary breast and ovarian cancer; key scaffold for homologous recombination DNA repair.
- 14. : Enzyme complex that maintains chromosome ends and enables replicative immortality.
- 16. : Tumor suppressor “guardian of the genome” that triggers cell-cycle arrest or apoptosis in DNA damage.