Across
- 4. Long acting inhaled insulin preparation (approved by US FDA in 2014, withdrawn from market, by EMA in 2018)
- 5. The longest acting insulin, which can be mixed with other insulins too
- 7. This DPP4 inhibitor does not requires dose adjustment in renal failure patients, but it increases risk of heart failure
- 11. Insulin secretion will_______by cholinergic-muscarinic activation by Ach
- 12. Only oral ADA that has been demonstrated to reduce macrovascular events in type 2 DM
- 15. The most potent insulinotropic sulfonyl urea, which has property of sequestered in beta cells
- 16. This organ receives the highest concentration of endogenous insulin but not the exogenous insulin
- 17. A hormone, which is a “universal inhibitor”, inhibits the release of insulin from beta cells
- 18. Insulin acts on this specific receptor located on cell membrane of every cells (practically)
- 19. This injectable ADA used in type 2 DM and recently approved for management of obesity
Down
- 1. Secreted by beta cells of pancreas along with insulin that also helps in decreasing blood sugar
- 2. The only drug approved for treatment of both type 1 DM as well as type 2 DM (other than insulin)
- 3. Beta blockers can mask all the warning signs of hypoglycaemia, except this one
- 6. Accumulation of this substance in tissue is responsible for long term complications in diabetes (like end organ damage)
- 8. A long acting insulin, should never mix with other insulin
- 9. This insulin can be given intravenously
- 10. The most rapidly acting insulin analogue
- 13. This ADR of insulin occurs due to local reaction on subcutaneous fat around injection site
- 14. Anemia long term use of metformin can result in this adverse effect
- 20. All insulin or insulin analogues preparations available at neutral pH, except this one, which is at pH 4