Topic 11. CELL INTERACTIONS AND EXTRACELLULAR MATRIX

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Across
  1. 4. Which type of CAM is best known for presenting foreign particles to immune cells?
  2. 6. Activated macrophages can produce MMPs that can degrade ECM giving rise to diseases, such as ___________
  3. 7. If a cell wanted to adhere to the ECM using actin filament what type of cell junction should it use?
  4. 9. This transmembrane protein comprised of CRP repeats and a lectin-like domain
  5. 11. Multicellular organism cannot exist without cell________
  6. 13. Proteoglycans have a net ______charge which binds Na+ and therefore attracts and retain water within the ECM.
  7. 15. _________proteins in ECM such as collagen and elastin provide tensile strength to the tissue.
Down
  1. 1. Selectins are involve in initiation _____________ involving migration of leukocytes along the vascular endothelium
  2. 2. ECM of the heart tissues include the hyaluronan, proteoglycan, collagen, fibronectin and ________ factors important for cardiomyocytes development and function.
  3. 3. This is an adhesive protein that connects integrin on cell surface to collagens in ECM.
  4. 5. This is the most abundant protein in the human body and a major component of the skin and bone.
  5. 8. ECM are produced intracellularly by resident cells and are secreted via __________
  6. 10. This is a Ca2+ dependant cell adhesion molecule.
  7. 12. This ECM component is found in lung, skin, bladder and cartilage and function to provide elasticity to these tissues.
  8. 14. What is the cell adhesion protein that functions to adhere cells to the ECM?