Topic 11. CELL INTERACTIONS & EXTRACELLULAR MATRIX

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Across
  1. 5. Selectins are involve in inflammatory response involving migration of __________ along the vascular endothelium
  2. 6. Is a fibrous protein in the ECM that provide elasticity to tissues in lung, skin and bladder.
  3. 7. An adhesive glycoprotein which is a heterotrimer and forms web-like structures and function in resisting tensile strength in the basal membrane.
  4. 10. Cultured cells generate their own ECM, while primary cultured cell requires exogenous provision of ECM by using _____________
  5. 12. This is an adhesive protein that connects integrin on cell surface to collagens in ECM.
  6. 15. ___________have a net negative charge which binds Na+ and therefore attracts and retain water within the ECM.
Down
  1. 1. Are Ca2+ dependant cell adhesion molecules involved in proper positioning and organization of cells in tissues or organs.
  2. 2. ECM of the heart tissues include the hyaluronan, proteoglycan, collagen, fibronectin and ________ factors important for cardiomyocytes development and function.
  3. 3. This is the most abundant protein in the human body and a major component of the skin and bone.
  4. 4. Over __________ of ECM due to production of MMPs by macrophages can result in arthritis.
  5. 8. Multicellular organism cannot exist without cell________
  6. 9. Comprised of heterodimeric transmembrane proteins that facilitates cells to ECM attachment
  7. 11. Which type of CAM is best known for presenting foreign particles to immune cells?
  8. 13. ECM are produced intracellularly by resident cells and are secreted via __________
  9. 14. _________can influence the structure presentation of antigens on surface of RBC membrane related to blood group type.