Across
- 3. An alternate approach for tissue therapy is to____________ terminally differentiated cells to dedifferentiate into multipotent proliferative cells with the capacity to regenerate all components of a damaged tissue.
- 5. For safety purposes, it is important to test the induced multipotent or pluripotent stem cells for ___________ potential or neoplastic growth.
- 7. In _________ cloning, nucleus from patient’s somatic cell is transfer to a enucleated oocyte from a donor to generate an embryo that can provide stem cells that is immunologically compatible with donor patient for transplantation.
- 8. The __________ of stem cells decreases when cells differentiate.
- 9. Stem cells renewal mechanisms include obligatory ___________replication and stochastic differentiation
- 10. Umbilical cord can be a source of multipotent stem cells which can be frozen for future therapeutic use and for ___________transfer.
- 11. Interspecies mating is prevented due to the _______ binding of protein on sperm to the receptor on egg cell.
- 12. The first cell cycles of fertilized egg are driven by ________ mRNA and proteins in the egg whereas subsequent cell divisions and protein synthesis are driven by the embryonic gene activation
- 14. When B-cell receptor (BCR) is autoreactive, SLP65 inhibit signal transduction, FOXO is unphosphorylated which will upregulate the transcription of Rag 1 and Rag 2 for activation of Ig light chain gene recombination leading to B-cell receptor class _________ and B cell differentiation or maturation.
Down
- 1. Pluripotent stem cells can be identified using distinct surface ______ to indicate the extent of differentiation.
- 2. Besides fibroblasts, ________can be reprogrammed into adult stem cells.
- 4. The formation and thickening of the fertilization envelop that surrounds the fertilised egg is caused by the_______ of hydrolytic enzymes stored in vesicles.
- 6. Stem cell lines developed in the lab need to undergo pluripotency assessment by ________test, comparing transcriptomic profile of the derived cell line with a reference stem cell in the database to rule out contamination as well as genetic and epigenetic abnormality that affects the gene expression pattern.
- 7. Stem cells that are from 1-2 cell stage of an embryo and have unlimited ability to form other cell or tissue types and even the embryo itself.
- 13. Hematopoietic Stem cells are multipotent blood stem cells comprising of the _____ and myeloid progenitor cells