Translation and Assembly

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Across
  1. 2. Proteins contain specific signals, amino acid pattern, that help localize proteins to different compartments, such as ___ localization signals.
  2. 3. Some paramyxoviral proteins have “weak” AUGs which enables multiple proteins to be produced by the same RNA, a process termed ___ scanning.
  3. 7. Viruses use polyproteins, suppression of termination, and alternative splicing to increase _____ capacity.
  4. 9. The eIF4E binds to the ___ of the mRNA.
  5. 11. Retroviral particles are not infectious until they bud from the cell and complete _____.
  6. 12. Viruses all use host cell ___ to produce proteins.
  7. 14. The process of an enveloped virus obtaining its lipid membrane.
  8. 15. Membrane proteins have ____ sequences to direct them to the membrane.
  9. 16. Secondary structures that enable cap independent translation.
  10. 18. Most DNA viruses package their genome in the ___ where they replicate their genome.
  11. 22. Viruses that do not form infectious particles within the cell use ____ assembly. The infectious particles are only produced as they bud from the plasma membrane.
Down
  1. 1. The process of making proteins.
  2. 4. Some viral RNAs encode “slippery” regions which cause the ribosome to slip back a base, altering the reading frame, a process called ribosomal ___.
  3. 5. ____ viral protease cuts eIF4G, preventing cellular protein production and promoting viral protein production.
  4. 6. Some RNAs contain secondary structure that enables the initiation complex to bypass regions and start translation at a later AUG, a process termed ribosomal ______.
  5. 8. Virus genomes contain _____ signals in order to ensure the genome is put into the particle.
  6. 10. Viruses, not being alive, do not grow, they are put together in an _______ ___ process.
  7. 13. Ribosomes bind to the 5’ cap to ______ most translation.
  8. 17. The eIF4G protein serves as a ___ to help circularize the mRNA, linking the cap to the polyA tail.
  9. 19. Partial structural units of a virus needed for assembly.
  10. 20. ____ domains recruit ESCRT machinery to help Enveloped viruses pinch the membrane off from the cell.
  11. 21. Viral assembly occurs when proteins and genome are at high enough _____, as nothing happens fast in dilute solutions.