Across
- 4. Abbreviation for activated fibroblasts that contribute to tumor progression
- 5. Protein that helps cancer evade T cell attack
- 8. Type of blood cancer affecting lymphocytes
- 12. These vascular cells form the inner lining of new blood vessels in the tumor microenvironment
- 14. Leading preventable cause of cancer worldwide
- 15. Enzyme that elongates telomeres in cancer cells
- 19. TME component responsible for mechanical stiffness
- 22. Permanent change in the DNA sequence of a gene
- 23. Guardian of the genome, often mutated in cancers
- 24. Type of immunity that provides rapid, non-specific defense against tumors and pathogens
- 26. Cancer of epithelial tissue
- 28. Substances that trigger an immune response by being recognized as foreign
- 32. General term for non-cancerous cells in TME
- 33. Process by which immune cells engulf and digest pathogens or dead cells
- 36. Granule-filled cells capable of killing tumor cells directly
- 37. T cell subtype that helps other immune cells
- 38. Essential molecule whose deficiency in tumors triggers angiogenesis
- 39. Tumor and immune cells communicate through these signaling molecules
- 40. Small signaling proteins that direct immune cell migration
Down
- 1. Cells that were used for to develop the first polio vaccine
- 2. Immune cells known for antibody production
- 3. Cancer cells often manipulate this system to avoid destruction
- 6. Innate immune cells that engulf pathogens and can be pro- or anti-tumor
- 7. Tumor type characterized by presence of immune cells and responsiveness to immunotherapy
- 9. Environment surrounding a tumor
- 10. Cells that help remember past infections
- 11. Receptor on T cells that binds to antigen–MHC complexes
- 13. Type of immunity that provides long-term protection through memory cell formation
- 16. Immune cells that present antigens
- 17. Proteins produced by B cells to recognize and bind specific antigens
- 18. Cell death often resisted by cancer cells
- 20. Cancer’s ability to colonize distant tissues
- 21. Process by which new blood vessels form
- 25. Cellular transition promoting invasion and metastasis
- 27. Signaling molecule that binds to receptors to promote proliferation and differentiation
- 29. White blood cells that include cytotoxic and helper types
- 30. Specialized immune cells that suppress T cell activity
- 31. Condition where the immune system attacks the body’s own cells
- 34. DNA segments frequently altered in tumors
- 35. Antigen-experienced T cells capable of direct tumor killing