Crossword 1

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Across
  1. 2. A process that changes the stability and accessibility of DNA
  2. 5. A terminology that describes mutations in the gene of certain enzymes
  3. 8. The total clearance of ceftazidime correlated ---------- with creatinine renal clearance in patients with varying degrees of renal function
  4. 10. One of the active metabolites of tamoxifen
Down
  1. 1. Type of castor oil that solubilizes paclitaxel for injectable preparations
  2. 3. fat meals absorption of the lipophilic drugs increased considerably when given with ------------
  3. 4. The bioavailability of ------------- was increased significantly from normal subjects to cirrhotic patients
  4. 6. The enzyme family responsible for IIV of tamoxifen
  5. 7. The renal clearance of ----------- has been shown to diminish with increasing urinary pH
  6. 9. Albumin-bound paclitaxel may facilitate the administration of ----- doses