Type I hypersensitivity

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Across
  1. 2. People who are more likely to have these reactions are called ___ individuals
  2. 6. For histamine release, mast cells (process name)
  3. 8. Reexposure to antigen can lead to a local reaction or systemic ____
  4. 12. This cytokine promotes Th2 cells and activates eosinophils
  5. 13. Secondary mediator-linked vasodilation can lead to ___
  6. 14. It takes ___ for this reaction to begin
  7. 16. A quick easy way to test for type 1 hypersensitivities
  8. 18. Mediators released by mast cells that enable SM contraction, vascular permeability and gland secretion are___
  9. 19. Secondary mediator creation uses which chemical pathway?
  10. 20. Are reactions only to harmless antigens?
  11. 21. The first stage of type 1 hypersensitivities is called the ___ phase
  12. 22. Mast cell degranulation releases histamine, chemotactic factors and ____
  13. 23. Itchiness is caused by the
Down
  1. 1. Late-phase reaction of the nose
  2. 2. This can be administered to counteract low blood pressure and bronchospasms
  3. 3. The effector phase involves the immediate hypersensitivity reaction and the ___ reaction
  4. 4. The second stage of this reaction is called the ___ phase
  5. 5. The effector phase happens after ___ to the antigen
  6. 7. Redness seen in type 1 hypersensitivity can be explained by ____
  7. 9. The main antibody involved here is ___
  8. 10. Respiratory effects of secondary mediators include
  9. 11. Type I hypersensitivities are classified as ____, due to their timeframe
  10. 15. Both primary and secondary mediators contribute to the production of ___
  11. 17. IgE binds to __ receptors during sensitisation
  12. 24. Atopic individuals have higher IgE levels because they have more IL-4 producing ___ cells